Multi scale and multi omic approaches in systems medicine

Prof. Pietro Lio', Computer Laboratory, University of Cambridge, UK
18/12/2015 - 11:30
Dipartimento di Matematica e Fisica Universita' degli Studi Roma Tre AULA 311 (SEMINARI) Largo San L. Murialdo,1

I will first introduce my current research on multi comics and multi scale modeling. Ductal carcinoma is one of the most common cancers among women, and the main cause of death is the formation of metastases. Through a branching process model, I describe the relation between the survival times
and the drivers mutations mainly involved in metastatic breast cancer. In particular, the model takes into account intracell to tissues dynamics in breast, blood and bone compartments and uses the gene expression profile of circulating tumour cells to predict personalised survival probability. I will end by introducing current work on logic approaches.